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About nine years ago on a sunny day in the loveliest of suburbs, in a town called Fairview, housewife Mary Alice Young (Brenda Strong) decided to end it all. Now she takes us into the lives of her friends, family and neighbors... Her circle of girlfriends on Wisteria Lane includes Bree Hodge (Marcia Cross), the owner of a thriving catering business and on the verge of publishing her first cookbook; Lynette Scavo (Felicity Huffman), who struggles with raising troublesome teenaged boys who have an affinity for breaking the law; Susan Mayer (Teri Hatcher), a single mom who is on a never-ending quest for love; the ex-model turned housewife Gabrielle Solis, who finds herself chasing after two daughters and looking drastically different from the model she once was.